Tennessee Titans upset Arizona Cardinals, 22–21

The Titans closed as 7.5-point underdogs and won outright. The betting market gave them a 22% chance.

It was the 2nd-biggest of 6 NFL upsets in 2025 Week 5, and the 9th-biggest of the 2025 season. Tennessee Titans pulled off 2 other upsets in 2025.

Other NFL upsets in 2025 Week 5

1. San Francisco 49ers 26, Los Angeles Rams 23

   8.5-point underdog22% to winOTRecap
   Upset size8.5
2. New England Patriots 23, Buffalo Bills 20

   7.5-point underdog23% to winRecap
   Upset size7.5
3. Denver Broncos 21, Philadelphia Eagles 17

   3.5-point underdog34% to winRecap
   Upset size3.5
4. Tampa Bay Buccaneers 38, Seattle Seahawks 35

   3.5-point underdog38% to winRecap
   Upset size3.5
5. Jacksonville Jaguars 31, Kansas City Chiefs 28

   3.5-point underdog36% to winRecap
   Upset size3.5

Tennessee Titans’ other 2025 upsets

1. Tennessee Titans 31, Cleveland Browns 29

   Week 144.5-point underdog36% to winRecap
   Upset size4.5
2. Tennessee Titans 26, Kansas City Chiefs 9

   Week 163.5-point underdog38% to winRecap
   Upset size3.5

More: Tennessee Titans upsets · Arizona Cardinals upsets · all Week 5 upsets · how upset size works