San Francisco 49ers upset Los Angeles Rams, 26–23

The 49ers closed as 8.5-point underdogs and won outright in overtime. The betting market gave them a 22% chance.

It was the biggest of 6 NFL upsets in 2025 Week 5, and the 5th-biggest of the 2025 season. San Francisco 49ers pulled off 1 other upset in 2025.

Other NFL upsets in 2025 Week 5

1. Tennessee Titans 22, Arizona Cardinals 21

   7.5-point underdog22% to winRecap
   Upset size7.5
2. New England Patriots 23, Buffalo Bills 20

   7.5-point underdog23% to winRecap
   Upset size7.5
3. Denver Broncos 21, Philadelphia Eagles 17

   3.5-point underdog34% to winRecap
   Upset size3.5
4. Tampa Bay Buccaneers 38, Seattle Seahawks 35

   3.5-point underdog38% to winRecap
   Upset size3.5
5. Jacksonville Jaguars 31, Kansas City Chiefs 28

   3.5-point underdog36% to winRecap
   Upset size3.5

San Francisco 49ers’ other 2025 upsets

1. San Francisco 49ers 23, Philadelphia Eagles 19

   Wild Card round6-point underdog30% to winRecap
   Upset size6

More: San Francisco 49ers upsets · Los Angeles Rams upsets · all Week 5 upsets · how upset size works