San Francisco 49ers beat Philadelphia Eagles, 23–19

The 49ers closed as 6-point underdogs and won outright. The betting market gave them a 30% chance.

It was the biggest of 1 NFL upset in 2025 Wild Card round, and the 20th-biggest of the 2025 season. San Francisco 49ers pulled off 1 other upset in 2025.

San Francisco 49ers’ other 2025 upsets

1. San Francisco 49ers 26, Los Angeles Rams 23

   Week 58.5-point underdog22% to winOTRecap
   Upset size8.5

More: San Francisco 49ers upsets · Philadelphia Eagles upsets · all Wild Card round upsets · how upset size works