San Francisco 49ers upset Seattle Seahawks, 33–30

The 49ers closed as 6.5-point underdogs and won outright in overtime.

All 2008 NFL Week 2 upsets, biggest first

An NFL upset is an underdog getting 3.5 or more points on the closing line winning outright. Upset size is the points it overcame. How it’s scored

1. San Francisco 49ers 33, Seattle Seahawks 30

   6.5-point underdogOTRecap
   Upset size6.5
2. Buffalo Bills 20, Jacksonville Jaguars 16

   4-point underdogRecap
   Upset size4
3. Oakland Raiders 23, Kansas City Chiefs 8

   3.5-point underdogRecap
   Upset size3.5