Jacksonville Jaguars beat San Francisco 49ers, 26–21

The Jaguars closed as 3.5-point underdogs and won outright. The betting market gave them a 38% chance.

It was the 2nd-biggest of 2 NFL upsets in 2025 Week 4, and the 43rd-biggest of the 2025 season. Jacksonville Jaguars pulled off 2 other upsets in 2025.

Other NFL upsets in 2025 Week 4

1. New York Giants 21, Los Angeles Chargers 18

   6-point underdog29% to winRecap
   Upset size6

Jacksonville Jaguars’ other 2025 upsets

1. Jacksonville Jaguars 34, Denver Broncos 20

   Week 163.5-point underdog39% to winRecap
   Upset size3.5
2. Jacksonville Jaguars 31, Kansas City Chiefs 28

   Week 53.5-point underdog36% to winRecap
   Upset size3.5

More: Jacksonville Jaguars upsets · San Francisco 49ers upsets · all Week 4 upsets · how upset size works