San Francisco 49ers upset St. Louis Rams, 24–20

The 49ers closed as 9-point underdogs and won outright.

It was the 2nd-biggest of 3 NFL upsets in 2005 Week 16, and the 8th-biggest of the 2005 season. San Francisco 49ers pulled off 2 other upsets in 2005.

Other NFL upsets in 2005 Week 16

1. Buffalo Bills 37, Cincinnati Bengals 27

   13-point underdogRecap
   Upset size13
2. Dallas Cowboys 24, Carolina Panthers 20

   5.5-point underdogRecap
   Upset size5.5

San Francisco 49ers’ other 2005 upsets

1. San Francisco 49ers 15, Tampa Bay Buccaneers 10

   Week 811.5-point underdogRecap
   Upset size11.5
2. San Francisco 49ers 28, St. Louis Rams 25

   Week 14.5-point underdogRecap
   Upset size4.5

More: San Francisco 49ers upsets · St. Louis Rams upsets · all Week 16 upsets · how upset size works