San Francisco 49ers beat St. Louis Rams, 28–25

The 49ers closed as 4.5-point underdogs and won outright.

It was the 5th-biggest of 5 NFL upsets in 2005 Week 1, and the 25th-biggest of the 2005 season. San Francisco 49ers pulled off 2 other upsets in 2005.

Other NFL upsets in 2005 Week 1

1. New Orleans Saints 23, Carolina Panthers 20

   6.5-point underdogRecap
   Upset size6.5
2. Tampa Bay Buccaneers 24, Minnesota Vikings 13

   6-point underdogRecap
   Upset size6
3. Dallas Cowboys 28, San Diego Chargers 24

   5-point underdogRecap
   Upset size5
4. Miami Dolphins 34, Denver Broncos 10

   4.5-point underdogRecap
   Upset size4.5

San Francisco 49ers’ other 2005 upsets

1. San Francisco 49ers 15, Tampa Bay Buccaneers 10

   Week 811.5-point underdogRecap
   Upset size11.5
2. San Francisco 49ers 24, St. Louis Rams 20

   Week 169-point underdogRecap
   Upset size9

More: San Francisco 49ers upsets · St. Louis Rams upsets · all Week 1 upsets · how upset size works