Clemson upsets No. 19 Louisville, 20–19

It was unranked Clemson taking down the No. 19 team in the AP poll.

It was the 7th-biggest of 11 upsets in 2025 Week 12, and the 108th-biggest of the 2025 season. It was Clemson's only upset win of 2025.

Other upsets in 2025 Week 12

1. Sam Houston 26, Delaware 23

   13.5-point underdogRecap
   Upset size13.5
2. No. 11 Oklahoma 23, No. 4 Alabama 21

   6.5-point underdogNo. 11 beat No. 4Recap
   Upset size10
3. Nevada 55, San José State 10

   9.5-point underdogRecap
   Upset size9.5
4. Navy 41, No. 25 South Florida 38

   8.5-point underdogUnranked beat No. 25Recap
   Upset size9
5. Arizona 30, No. 22 Cincinnati 24

   6.5-point underdogUnranked beat No. 22Recap
   Upset size8.5

More: Clemson upsets · Louisville upsets · all Week 12 upsets · the 2025 season · how upset size works