Louisville Cardinals

Upsets Louisville pulled off

1. No. 23 Louisville 41, No. 16 SMU 31

   Week 3No. 23 beat No. 16Recap
   Upset size3.5

Times Louisville was upset

1. NC State 31, Louisville 28

   Week 55.5-point underdogRecap
   Upset size5.5
2. Wake Forest 30, No. 16 Louisville 27

   Week 411.5-point underdogUnranked beat No. 16Recap
   Upset size16.5

All-time since 2000

Biggest upsets Louisville pulled off

1. Louisville 24, No. 2 Miami 21

   2025Week 810.5-point underdogUnranked beat No. 2Recap
   Upset size22.5
2. Louisville 33, No. 11 Clemson 21

   2024Week 1011.5-point underdogUnranked beat No. 11Recap
   Upset size19
3. No. 25 Louisville 33, No. 10 Notre Dame 20

   2023Week 66-point underdogNo. 25 beat No. 10Recap
   Upset size13.5
4. Louisville 48, No. 10 Wake Forest 21

   2022Week 93-point underdogUnranked beat No. 10Recap
   Upset size11
5. Louisville 26, No. 4 Florida State 20

   2002Week 6Unranked beat No. 4Recap
   Upset size11

Worst times Louisville was upset

1. Kentucky 41, No. 11 Louisville 38

   2016Week 1326-point underdogUnranked beat No. 11Recap
   Upset size33.5
2. Houston 36, No. 3 Louisville 10

   2016Week 1217-point underdogUnranked beat No. 3Recap
   Upset size28.5
3. UCF 38, No. 8 Louisville 35

   2013Week 817.5-point underdogUnranked beat No. 8Recap
   Upset size26.5
4. California 29, No. 14 Louisville 26

   2025Week 1118.5-point underdogUnranked beat No. 14Recap
   Upset size24.5
5. Stanford 38, No. 22 Louisville 35

   2024Week 1220.5-point underdogUnranked beat No. 22Recap
   Upset size22.5