College football · NFLTuesday, October 13, 2026
The Upset Report
NFL · 2021 · Week 1 · Sunday, September 12, 2021

Pittsburgh Steelers upset Buffalo Bills, 23–16

The Steelers closed as 6.5-point underdogs and won outright. The betting market gave them a 29% chance.

Final23–16
Upset size6.5
Chance to win29%
Rank in 202126th of 58

It was the biggest of 5 NFL upsets in 2021 Week 1, and the 26th-biggest of the 2021 season. Pittsburgh Steelers pulled off 2 other upsets in 2021.

Other NFL upsets in 2021 Week 1

  1. 4-point underdog37% to winRecap
    Upset size4
  2. 3.5-point underdog37% to winRecap
    Upset size3.5
  3. 3.5-point underdog38% to winRecap
    Upset size3.5
  4. 3.5-point underdog38% to winRecap
    Upset size3.5

Pittsburgh Steelers’ other 2021 upsets

  1. Week 85.5-point underdog33% to winRecap
    Upset size5.5
  2. Week 134-point underdog36% to winRecap
    Upset size4

More: Pittsburgh Steelers upsets · Buffalo Bills upsets · all Week 1 upsets · how upset size works