College football · NFLTuesday, October 13, 2026
The Upset Report
NFL · 2008 · Week 13 · Sunday, November 30, 2008

San Francisco 49ers upset Buffalo Bills, 10–3

The 49ers closed as 6.5-point underdogs and won outright. The betting market gave them a 29% chance.

Final10–3
Upset size6.5
Chance to win29%
Rank in 200817th of 46

It was the 2nd-biggest of 3 NFL upsets in 2008 Week 13, and the 17th-biggest of the 2008 season. San Francisco 49ers pulled off 2 other upsets in 2008.

Other NFL upsets in 2008 Week 13

  1. 7.5-point underdog24% to winRecap
    Upset size7.5
  2. 6.5-point underdog30% to winRecap
    Upset size6.5

San Francisco 49ers’ other 2008 upsets

  1. Upset size6.5
  2. Week 144-point underdog33% to winRecap
    Upset size4

More: San Francisco 49ers upsets · Buffalo Bills upsets · all Week 13 upsets · how upset size works