Duke upsets Clemson, 46–45

Duke closed as a 4.5-point underdog and won outright.

It was the 13th-biggest of 17 upsets in 2025 Week 10, and the 143rd-biggest of the 2025 season. Duke pulled off 1 other upset in 2025.

Other upsets in 2025 Week 10

1. Fresno State 30, Boise State 7

   17.5-point underdogRecap
   Upset size17.5
2. West Virginia 45, No. 22 Houston 35

   12.5-point underdogUnranked beat No. 22Recap
   Upset size14.5
3. SMU 26, No. 10 Miami 20

   6.5-point underdogUnranked beat No. 10Recap
   Upset size14.5
4. NC State 48, No. 8 Georgia Tech 36

   4.5-point underdogUnranked beat No. 8Recap
   Upset size13.5
5. Kentucky 10, Auburn 3

   11.5-point underdogRecap
   Upset size11.5

Duke’s other 2025 upsets

1. Duke 27, No. 16 Virginia 20

   Week 153.5-point underdogUnranked beat No. 16Recap
   Upset size8.5

More: Duke upsets · Clemson upsets · all Week 10 upsets · the 2025 season · how upset size works