Syracuse stuns Clemson, 34–21

Syracuse closed as a 17.5-point underdog and won outright.

It was the biggest of 13 upsets in 2025 Week 4, and the 12th-biggest of the 2025 season. It was Syracuse's only upset win of 2025.

Other upsets in 2025 Week 4

1. Coastal Carolina 38, South Alabama 20

   14.5-point underdogRecap
   Upset size14.5
2. San Diego State 34, California 0

   13.5-point underdogRecap
   Upset size13.5
3. Western Michigan 14, Toledo 13

   11.5-point underdogRecap
   Upset size11.5
4. Tulsa 19, Oklahoma State 12

   10.5-point underdogRecap
   Upset size10.5
5. Maryland 27, Wisconsin 10

   10.5-point underdogRecap
   Upset size10.5

More: Syracuse upsets · Clemson upsets · all Week 4 upsets · the 2025 season · how upset size works