Southern Miss stuns Louisiana Tech, 35–19
Southern Miss closed as a 15.5-point underdog and won outright.
Final35–19
Upset size15.5
Rank in 202129th of 199
It was the biggest of 13 upsets in 2021 Week 12, and the 29th-biggest of the 2021 season. It was Southern Miss's only upset win of 2021.
Other upsets in 2021 Week 12
No. 24 Utah 38, 
No. 4 Oregon 7Upset size10- Upset size9
South Carolina 21, 
Auburn 17Upset size7
Clemson 48, 
No. 13 Wake Forest 27Upset size6.5
Colorado 20, 
Washington 17Upset size6.5
More: Southern Miss upsets · Louisiana Tech upsets · all Week 12 upsets · the 2021 season · how upset size works