Cincinnati Bengals beat Buffalo Bills, 27–10

The Bengals closed as 6-point underdogs and won outright. The betting market gave them a 30% chance.

It was the biggest of 1 NFL upset in 2022 Divisional round, and the 18th-biggest of the 2022 season. It was Cincinnati Bengals's only upset win of 2022.

More: Cincinnati Bengals upsets · Buffalo Bills upsets · all Divisional round upsets · how upset size works