College football · NFLTuesday, October 13, 2026
The Upset Report
NFL · 2021 · Week 16 · Thursday, December 23, 2021

Tennessee Titans beat San Francisco 49ers, 20–17

The Titans closed as 3.5-point underdogs and won outright. The betting market gave them a 38% chance.

Final20–17
Upset size3.5
Chance to win38%
Rank in 202154th of 58

It was the 3rd-biggest of 3 NFL upsets in 2021 Week 16, and the 54th-biggest of the 2021 season. Tennessee Titans pulled off 4 other upsets in 2021.

Other NFL upsets in 2021 Week 16

  1. 13.5-point underdog16% to winRecap
    Upset size13.5
  2. 7-point underdog26% to winRecap
    Upset size7

Tennessee Titans’ other 2021 upsets

  1. Week 97-point underdog25% to winRecap
    Upset size7
  2. Week 26.5-point underdog28% to winOTRecap
    Upset size6.5
  3. Week 66-point underdog31% to winRecap
    Upset size6
  4. Week 74-point underdog34% to winRecap
    Upset size4

More: Tennessee Titans upsets · San Francisco 49ers upsets · all Week 16 upsets · how upset size works