College football · NFLTuesday, October 13, 2026
The Upset Report
NFL · 2006 · Week 16 · Sunday, December 24, 2006

Arizona Cardinals beat San Francisco 49ers, 26–20

The Cardinals closed as 3.5-point underdogs and won outright. The betting market gave them a 37% chance.

Final26–20
Upset size3.5
Chance to win37%
Rank in 200657th of 59

It was the 7th-biggest of 7 NFL upsets in 2006 Week 16, and the 57th-biggest of the 2006 season. Arizona Cardinals pulled off 1 other upset in 2006.

Other NFL upsets in 2006 Week 16

  1. 9-point underdog20% to winRecap
    Upset size9
  2. 6.5-point underdog28% to winRecap
    Upset size6.5
  3. 6-point underdog31% to winRecap
    Upset size6
  4. 5.5-point underdog31% to winRecap
    Upset size5.5
  5. 4-point underdog35% to winRecap
    Upset size4

Arizona Cardinals’ other 2006 upsets

  1. Week 136-point underdog32% to winRecap
    Upset size6

More: Arizona Cardinals upsets · San Francisco 49ers upsets · all Week 16 upsets · how upset size works